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Stable Fluorophosphines: Predicted and Realized Ligands for Catalysis


  • We whould like to thank the EPSRC (Grant No. EP/E059376/1 to N.F.), COST Network CM0802, and Rhodia for support and Johnson–Matthey for the loan of precious metals.


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Ligand maps lead to treasure! The activity of complexes of fluorophosphines (R2PF) in catalytic hydroformylation and hydrocyanation is predicted from a ligand map. However, the instability of R2PF to disproportionation is well-documented. Examples of R2PF ligands (see scheme) are described that are stabilized to such an extent that they can be used in catalysis and are shown to be highly effective.