We gratefully acknowledge the generous financial support of this research by the Hans-Fischer-Gesellschaft München. We are also indebted to Prof. H. Mayr and Dr. A. Ofial, LMU München, for their collegial help and permission to use their ITC instrument. We also thank Prof. Vladimir Král, Technical University of Prague, for directing our attention to the unique properties of COSAN dioxanate.
Selective Host–Guest Binding of Anions without Auxiliary Hydrogen Bonds: Entropy as an Aid to Design†
Article first published online: 18 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 1, pages 242–246, January 2, 2012
How to Cite
Ursu, A. and Schmidtchen, F. P. (2012), Selective Host–Guest Binding of Anions without Auxiliary Hydrogen Bonds: Entropy as an Aid to Design. Angew. Chem. Int. Ed., 51: 242–246. doi: 10.1002/anie.201106018
- Issue published online: 29 DEC 2011
- Article first published online: 18 NOV 2011
- Manuscript Received: 25 AUG 2011
- Hans-Fischer-Gesellschaft München
- cage compounds;
- enthalpy–entropy compensation;
- host–guest systems
Entropy matters! In contrast to classic host–guest design, which employs dedicated enthalpic interactions of the binding partners, the novel electroneutral host 1 binds its anionic guests by virtue of an overwhelmingly positive entropy of association. The prime driving force is guest desolvation. Despite the total omission of hydrogen bonding, host 1 is one of the best electroneutral receptors known for binding anions in polar solution.