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Keywords:

  • amino aldehydes;
  • amphoteric molecule;
  • chemoselectivity;
  • hydantoin;
  • regioselectivity
Thumbnail image of graphical abstract

Latched on: A new class of hydantoin derivatives with three contiguous stereocenters was prepared from a [3+2] annulation involving amphoteric aziridine aldehydes and isocyanates and further converted to a series of densely functionalized hetercycles, which are difficult to synthesize using established methods. The results highlight the potential of (1,3) amphoteric molecules to construct heterocyclic scaffolds using trivial starting materials.