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Production and NMR Characterization of Hyperpolarized 107,109Ag Complexes

Authors

  • Dr. Lloyd Lumata,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
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  • Prof. Dr. Matthew E. Merritt,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
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  • Zohreh Hashami,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
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  • Dr. S. James Ratnakar,

    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
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  • Prof. Dr. Zoltan Kovacs

    Corresponding author
    1. Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
    • Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 (USA)
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  • This work is supported by the NIH (grant number R21EB009147).

Abstract

original image

Both isotopes of silver, 107Ag and 109Ag, were simultaneously polarized by dynamic nuclear polarization (DNP), thus allowing large signal enhancements and the NMR characterization of Ag complexes in the millimolar concentration range. Since both isotopes have long relaxation times T1, the hyperpolarized NMR signal of one isotope could still be observed even after the magnetization of the other isotope had been destroyed by radio-frequency pulses.

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