Communication

Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two-Photon Luminescence Imaging and Cell Therapy†

  1. Dr. Jing-Liang Li1,‡,
  2. Dr. Hong-Chun Bao2,‡,
  3. Xue-Liang Hou1,‡,
  4. Lu Sun1,
  5. Prof. Xun-Gai Wang1,*,
  6. Prof. Min Gu2,*

Article first published online: 13 JAN 2012

DOI: 10.1002/anie.201106102

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, pages 1830–1834, February 20, 2012

Additional Information

How to Cite

Li, J.-L., Bao, H.-C., Hou, X.-L., Sun, L., Wang, X.-G. and Gu, M. (2012), Graphene Oxide Nanoparticles as a Nonbleaching Optical Probe for Two-Photon Luminescence Imaging and Cell Therapy. Angew. Chem. Int. Ed., 51: 1830–1834. doi: 10.1002/anie.201106102

Author Information

  1. 1

    Centre for Material and Fiber Innovation, Deakin University, Waurn Ponds, Vic 3216 (Australia)

  2. 2

    Centre for Micro-Photonics, Swinburne University of Technology, Hawthorn, Vic 3122 (Australia)

  1. ‡

    These authors contributed equally to this work.

*Centre for Material and Fiber Innovation, Deakin University, Waurn Ponds, Vic 3216 (Australia)

  1. †

    We would like to thank Dr. Xiangping Li for assistance with the TPL spectrum measurement, Dr. Luhua Li for assistance with AFM analysis, Mandy Ludford-Menting for help with cell preparation during the revision of this manuscript, and Prof. Saulius Juodkazis for helpful discussions.

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 13 JAN 2012
  3. Manuscript Revised: 13 OCT 2011
  4. Manuscript Received: 29 AUG 2011

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Keywords:

  • cancer;
  • graphene oxide;
  • imaging agents;
  • photothermal therapy;
  • two-photon luminescence
Thumbnail image of graphical abstract

Lasting glow: Under femtosecond laser irradiation, graphene oxide nanoparticles (GONs) give strong two-photon luminescence (TPL; see picture). The presence of GONs also induces microbubbling, which causes cell death at an order of magnitude lower laser power than when cells are not labeled. The results show that GONs can be used for TPL-based imaging and photothermal cancer therapy.

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