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Communication

Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid†

  1. Dr. Satoshi Yamaguchi1,*,
  2. Shinya Yamahira2,
  3. Kyoko Kikuchi3,
  4. Kimio Sumaru3,
  5. Toshiyuki Kanamori3,
  6. Prof. Teruyuki Nagamune1,2,*

Article first published online: 21 NOV 2011

DOI: 10.1002/anie.201106106

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 1, pages 128–131, January 2, 2012

Additional Information

How to Cite

Yamaguchi, S., Yamahira, S., Kikuchi, K., Sumaru, K., Kanamori, T. and Nagamune, T. (2012), Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid. Angew. Chem. Int. Ed., 51: 128–131. doi: 10.1002/anie.201106106

Author Information

  1. 1

    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

  2. 2

    Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

  3. 3

    Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 (Japan)

*Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan)

  1. †

    This work was supported by the Center for NanoBio Integration in The University of Tokyo.

Publication History

  1. Issue published online: 29 DEC 2011
  2. Article first published online: 21 NOV 2011
  3. Manuscript Received: 29 AUG 2011

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Keywords:

  • cell adhesion;
  • cell patterning;
  • microarrays;
  • microfluids;
  • photolysis
Thumbnail image of graphical abstract

Cells in the spotlight: A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG-coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high-contrast cell pattern. Only the targeted cells on the cell pattern were selectively detached without cell damage on a microfluidic device (see picture).

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