This work was supported by the Center for NanoBio Integration in The University of Tokyo.
Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid†
Article first published online: 21 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 1, pages 128–131, January 2, 2012
How to Cite
Yamaguchi, S., Yamahira, S., Kikuchi, K., Sumaru, K., Kanamori, T. and Nagamune, T. (2012), Photocontrollable Dynamic Micropatterning of Non-adherent Mammalian Cells Using a Photocleavable Poly(ethylene glycol) Lipid. Angew. Chem. Int. Ed., 51: 128–131. doi: 10.1002/anie.201106106
- Issue published online: 29 DEC 2011
- Article first published online: 21 NOV 2011
- Manuscript Received: 29 AUG 2011
- cell adhesion;
- cell patterning;
Cells in the spotlight: A substrate was coated with a poly(ethylene glycol) (PEG) segment bound to a lipid through a linker that was cleaved by UV irradiation to leave a PEG-coated area. Irradiation of an arbitrary pattern easily and rapidly yielded a high-contrast cell pattern. Only the targeted cells on the cell pattern were selectively detached without cell damage on a microfluidic device (see picture).