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Total Synthesis of Tulearin C


  • Generous financial support by the MPG and the Fonds der Chemischen Industrie is gratefully acknowledged. We thank the analytical departments of our Institute for excellent support.


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With the help of the smaller brother: Although alkyne metathesis will always be the little brother of alkene metathesis, it allows problems to be solved that are currently beyond reach of the more famous sibling. This notion is exemplified by the tulearin macrolides, which could only be selectively forged by ring-closing alkyne metathesis (RCAM)/trans reduction using the latest generation of alkyne metathesis catalysts.

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