Visiting research fellow from DiSCAFF.
Transition-Metal-Free Direct Arylation of Anilines†
Article first published online: 12 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 1006–1009, January 23, 2012
How to Cite
Pirali, T., Zhang, F., Miller, A. H., Head, J. L., McAusland, D. and Greaney, M. F. (2012), Transition-Metal-Free Direct Arylation of Anilines. Angew. Chem. Int. Ed., 51: 1006–1009. doi: 10.1002/anie.201106150
We thank Regione Piemonte, DRUIDI project (visiting research fellowship to T.P.) and the EPSRC for funding (Leadership Fellowship to M.F.G.), and the EPSRC mass spectrometry service at the University of Swansea.
- Issue published online: 17 JAN 2012
- Article first published online: 12 DEC 2011
- Manuscript Revised: 31 OCT 2011
- Manuscript Received: 30 AUG 2011
- Regione Piemonte
- CH bond activation
Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes.