Multifunctional Mesoporous Composite Nanocapsules for Highly Efficient MRI-Guided High-Intensity Focused Ultrasound Cancer Surgery

Authors

  • Dr. Yu Chen,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Prof. Dr. Hangrong Chen,

    Corresponding author
    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
    • State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Dr. Yang Sun,

    1. Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 (P.R. China)
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  • Prof. Dr. Yuanyi Zheng,

    1. Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010 (P.R. China)
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  • Prof. Dr. Deping Zeng,

    1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016 (P.R. China)
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  • Prof. Dr. Faqi Li,

    1. State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016 (P.R. China)
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  • Dr. Shengjian Zhang,

    1. Department of Radiology, Cancer Hospital/Institute & Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 (P.R. China)
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  • Dr. Xia Wang,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Dr. Kun Zhang,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Dr. Ming Ma,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Dr. Qianjun He,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Dr. Linlin Zhang,

    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • Prof. Dr. Jianlin Shi

    Corresponding author
    1. State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
    • State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050 (P.R. China)
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  • MRI=magnetic resonance imaging. This work was supported by the National Basic Research Program of China (973 Program, Grant No. 2011CB707905), Shanghai Rising-Star Program (Grant No. 10QH1402800), National Nature Science Foundation of China (Grant No. 51132009, 50823007, 50972154, 51072212, 51102259), the Science Foundation for Youth Scholar of State Key Laboratory of High Performance Ceramics and Superfine Microstructures (Grant No. SKL201001), CASKJCX Projects (Grant No. KJCX2-YW-210) and the Science and Technology Commission of Shanghai (Grant No. 10430712800, 10QH1402800).

Abstract

original image

Bloodless surgical knife: Nano-biotechnology has been introduced into imaging-guided high-intensity focused ultrasound (HIFU) cancer surgery by adopting engineered multifunctional manganese-based mesoporous composite nanocapsules as the contrast agents for T1-weighted magnetic resonance imaging (MRI) and simultaneously as synergistic agents for MRI-guided HIFU cancer surgery.

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