These authors contributed equally to this work.
Mechanism of UV-Induced Formation of Dewar Lesions in DNA †
Article first published online: 23 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 2, pages 408–411, January 9, 2012
How to Cite
Haiser, K., Fingerhut, B. P., Heil, K., Glas, A., Herzog, T. T., Pilles, B. M., Schreier, W. J., Zinth, W., de Vivie-Riedle, R. and Carell, T. (2012), Mechanism of UV-Induced Formation of Dewar Lesions in DNA . Angew. Chem. Int. Ed., 51: 408–411. doi: 10.1002/anie.201106231
We thank the DFG (SFB 749) for financial support.
- Issue published online: 4 JAN 2012
- Article first published online: 23 NOV 2011
- Manuscript Received: 2 SEP 2011
- ab initio calculations;
- Dewar valence isomer;
- DNA damage;
- time-resolved IR spectroscopy;
- UV irradiation
The importance of a backbone: The mechanism of formation of Dewar lesions (see scheme) has been investigated by using femtosecond IR spectroscopy and ab initio calculations of the exited state. The 4π electrocyclization is rather slow, occurs with an unusual high quantum yield, and—surprisingly—is controlled by the phosphate backbone.