A Synthetic Approach Toward a Self-Regulated Insulin Delivery System

Authors

  • Dr. Akira Matsumoto,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Dr. Takehiko Ishii,

    1. Department of Bioengineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)
    Search for more papers by this author
    • These authors contributed equally to this work.

  • Junko Nishida,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    Search for more papers by this author
  • Dr. Hiroko Matsumoto,

    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    Search for more papers by this author
  • Dr. Kazunori Kataoka,

    1. Department of Materials Science and Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan)
    Search for more papers by this author
  • Dr. Yuji Miyahara

    Corresponding author
    1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    • Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Kanda-surugadai 2-3-10, Chiyoda-ku, Tokyo 101-0062 (Japan)
    Search for more papers by this author

  • This research is supported by the Japan Science and Technology Agency (JST), Core Research of Evolutional Science & Technology (CREST), and, in part, by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP).

Abstract

original image

Protein-free: A hydrogel containing phenylboronate was optimized so as to undergo rapid glucose-dependent changes in the state of hydration under physiological aqueous conditions. A localized dehydration of the gel surface to form a “skin layer” enabled control of the release of insulin from the gel. This dehydration is induced by fluctuations in the glucose concentration in the range between normo- and hyperglycemia.

Ancillary