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In Vitro Developmental Acceleration of Hippocampal Neurons on Nanostructures of Self-Assembled Silica Beads in Filopodium-Size Ranges


  • This work was supported by the Korea Research Foundation Grant funded by the Korean Government (MOEHRD, KRF-2008-313-d00614) and the Basic Science Research Programs through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0001318, 2009-0077751, 2009-0080081, and 2010-0025065) and the Brain Research Center of the 21st Century Frontier Research Program.


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Something to sprout about: The developmental acceleration of hippocampal neurons occurred on well-packed structures of silica beads with diameters over 200 nm (see picture; scale bar: 5 μm, inset scale bar: 1 μm). The neurons sensed the size differences of the nanostructures and altered their behaviors, thus implying that nanotopographical stimuli are one of the important features for guiding neurites during neural developments in vivo.