Communication

The Direct Asymmetric α Alkylation of Ketones by Brønsted Acid Catalysis†

  1. Liu Song,
  2. Prof. Qi-Xiang Guo*,
  3. Xing-Cheng Li,
  4. Juan Tian,
  5. Prof. Yun-Gui Peng*

Article first published online: 19 JAN 2012

DOI: 10.1002/anie.201106275

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, pages 1899–1902, February 20, 2012

Additional Information

How to Cite

Song, L., Guo, Q.-X., Li, X.-C., Tian, J. and Peng, Y.-G. (2012), The Direct Asymmetric α Alkylation of Ketones by Brønsted Acid Catalysis. Angew. Chem. Int. Ed., 51: 1899–1902. doi: 10.1002/anie.201106275

Author Information

  1. Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China)

*Education Ministry Key Laboratory on Luminescence and Real-Time Analysis, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715 (China)

  1. †

    We are grateful for financial support from NSFC (20902074) and the financial support from the Fundamental Research Funds for the Central Universities (XDJK2011C054).

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 19 JAN 2012
  3. Manuscript Revised: 16 NOV 2011
  4. Manuscript Received: 5 SEP 2011

Funded by

  • NSFC. Grant Number: 20902074
  • Fundamental Research Funds for the Central Universities. Grant Number: XDJK2011C054

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Keywords:

  • alkylation;
  • Brønsted acid;
  • indole;
  • organocatalysis;
  • synthetic methods
Thumbnail image of graphical abstract

Being direct: A Brønsted acid catalyzed α alkylation of ketones is described. The phosphoric acid 1 promotes this reaction to afford the desired products with high yields, high diastereoselectivities, and good to excellent enantioselectivites.

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