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Catalytic Asymmetric Diastereodivergent Deracemization


  • We are grateful to the Max-Planck-Society and the Max-Planck-Institut für Kohlenforschung for generous support of our research programs. This work was funded by the Deutsche Forschungsgemeinschaft (DFG Grant MA 4861/3-1), the Alexander von Humboldt Foundation (Fellowship to M.L.) and the Fonds der Chemischen Industrie (equipment grant to N.M.). We acknowledge Mr. H. Teller and Prof. A. Fürstner (MPI Mülheim) for a generous donation of ligand L1a, Ms. D. Klutt and Mrs. B. Gabor (MPI Mülheim) for analytical determinations (HPLC and NMR spectroscopy) and Dr. M. Klußmann (MPI Mülheim) and Prof. G. Helmchen (Uni. Heidelberg) for helpful discussions.


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Your wish is my command: Deracemization is a powerful strategy wherein a racemate is converted into a 100 % yield of a single enantiopure product. A new concept in catalytic deracemization is presented, in which a racemate with n stereogenic elements can be selectively converted into each one of 2m (m=number of chiral centers of the product) different enantiopure products, by simple tuning of the reaction conditions.