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Keywords:

  • antitumor agents;
  • cancer;
  • duocarmycin;
  • natural products;
  • proteomics
Thumbnail image of graphical abstract

Reacquiring the target: A proteomic profiling approach has been used to show that aldehyde dehydrogenase 1 may be an additional or alternative target of duocarmycin. Selective inhibition of this enzyme in lung cancer cells explains the antitumor activity of duocarmycin analogues (see scheme).