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Variation of the Glycosylation Pattern in MUC1 Glycopeptide BSA Vaccines and Its Influence on the Immune Response

Authors

  • Hui Cai,

    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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    • These authors contributed equally to this work.

  • Zhi-Hua Huang,

    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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    • These authors contributed equally to this work.

  • Lei Shi,

    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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  • Zhan-Yi Sun,

    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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  • Prof. Dr. Yu-Fen Zhao,

    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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  • Prof. Dr. Horst Kunz,

    Corresponding author
    1. Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz (Germany)
    • Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz (Germany)
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  • Prof. Dr. Yan-Mei Li

    Corresponding author
    1. Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
    • Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084 (P.R. China)
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    • These authors contributed equally to this work.


  • This work was supported by the National Natural Science Fundation of China (20825206 and 21028004) and the Sino–German Center for Research Promotion (GZ561).

Abstract

original image

A shot in the arm for anticancer vaccines: Synthetic MUC1 glycopeptides bearing the STn and 2,6-ST antigens were conjugated covalently to BSA (see scheme). The obtained synthetic vaccines induced very strong immune responses in Balb/c mice. Predominant IgG isotype antibodies were induced. The antibodies exhibited strong binding to breast cancer cells of the MCF-7 cell line.

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