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Keywords:

  • biarsenical compounds;
  • dimerization;
  • protein cross-linking;
  • protein–protein interactions;
  • small molecules
Thumbnail image of graphical abstract

As you like it: xCrAsH, a dimeric derivative of the arsenical compound FlAsH, enables the highly specific, covalent cross-linking of two proteins containing a 12 amino acid peptide tag. This inducible and (by addition of dithiols) reversible system can be used to detect and manipulate protein–protein interactions both in vitro and in living cells (see picture).