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Palladium-Catalyzed Decarboxylative C[BOND]H Bond Arylation of Thiophenes

Authors

  • Dr. Peng Hu,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002 (China)
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  • Min Zhang,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002 (China)
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  • Xiaoming Jie,

    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002 (China)
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  • Prof. Weiping Su

    Corresponding author
    1. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002 (China)
    • State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Yangqiao West Road 155, Fuzhou, Fujian 350002 (China)
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  • Financial support from the 973 Program (2011CB932404, 2011CBA00501), NSFC (20821061, 20925102), “The Distinguished Oversea Scholar Project”, the “One Hundred Talent Project”, the Knowledge Innovation Program of CAS, and the Key Project from CAS is greatly appreciated.

Abstract

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An efficient method involving a Pd/PCy3 catalyst in combination with a stoichiometric amount of Ag2CO3 has been established for the decarboxylative C[BOND]H bond arylation of thiophenes to give 2-arylthiophenes (see scheme; Cy=cyclohexyl). Electron-rich, electron-deficient, and heterocyclic benzoic acids can be used as the arylating reagent and a broad range of substituents on the thiophene are tolerated.

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