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The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR-21 Function by Directly Targeting Its Precursor

Authors

  • Debojit Bose,

    1. Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
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  • Gopal Jayaraj,

    1. Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
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  • Hemant Suryawanshi,

    1. Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
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  • Prachi Agarwala,

    1. Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
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  • Subrata Kumar Pore,

    1. Department of Lipid Science & Technology, Indian Institute of Chemical Technology, CSIR, Hyderabad 500607 (India)
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  • Dr. Rajkumar Banerjee,

    1. Department of Lipid Science & Technology, Indian Institute of Chemical Technology, CSIR, Hyderabad 500607 (India)
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  • Dr. Souvik Maiti

    Corresponding author
    1. Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
    2. National Chemical Laboratory, CSIR, Pune 411008 (India)
    • Proteomics and Structural Biology Unit, Institute of Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110007 (USA)
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  • This work was supported by the Council of Scientific and Industrial Research (CSIR) (project title: Comparative Genomics and Biology of Noncoding RNA), India. We also thank Dr. Teena Goel for helping with the in silico docking studies.

Abstract

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No dice: MicroRNAs (miRNAs) fine-tune gene expression, deregulation of which has been causally associated with a number of debilitating conditions. Streptomycin, a well-known aminoglycoside drug, binds to RNA secondary structures and is shown to inhibit miR-21 function by direct binding to its precursor, thus presumably interfering with the processing by the Dicer enzyme (see scheme).

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