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Keywords:

  • asymmetric catalysis;
  • hydrogenation;
  • iridium;
  • P,N ligands;
  • spiroketals
Thumbnail image of graphical abstract

From spiro to spiro: An iridium(I) complex with a spiral P,N ligand (SpinPhox) is highly efficient in the catalytic asymmetric hydrogenation of α,α′-bis(2-hydroxyarylidene) ketones to afford the corresponding aromatic spiroketals in high yields with excellent diastereo- and enantioselectivities (see scheme). The complex plays a dual role in the reaction, acting as catalyst for both the hydrogenation of C[DOUBLE BOND]C bonds and the subsequent spiroketalization of bisphenolic ketones.