These authors contributed equally to this work.
Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China†
Article first published online: 27 JAN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 10, pages 2368–2370, March 5, 2012
How to Cite
Zhou, Z.-Y., Shi, G.-Q., Fontaine, R., Wei, K., Feng, T., Wang, F., Wang, G.-Q., Qu, Y., Li, Z.-H., Dong, Z.-J., Zhu, H.-J., Yang, Z.-L., Zeng, G. and Liu, J.-K. (2012), Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China. Angew. Chem. Int. Ed., 51: 2368–2370. doi: 10.1002/anie.201106502
This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, U1132607), and Scientific Research Special Funds from the Ministry of Health (200802002). We thank Dr. R. Stone for reading our manuscript and for helpful suggestions.
- Issue published online: 1 MAR 2012
- Article first published online: 27 JAN 2012
- Manuscript Revised: 21 DEC 2011
- Manuscript Received: 14 SEP 2011
- National Basic Research Program of China. Grant Number: 2009CB522300
- National Natural Sciences Foundation of China. Grant Numbers: 30830113, U1132607
- Ministry of Health. Grant Number: 200802002
- amino acids;
- natural products;
Life saver: Two unusual and toxic amino acids, 2R-amino-4S-hydroxy-5-hexynoic acid (red, see scheme) and 2R-amino-5-hexynoic acid (blue) have been isolated from the fruiting bodies of the mushroom Trogia venenata. Toxicology studies suggest that these compounds may be the cause of Sudden Unexplained Death (SUD) in Yunnan Province, China.