Evidence for the Natural Toxins from the Mushroom Trogia venenata as a Cause of Sudden Unexpected Death in Yunnan Province, China

Authors

  • Dr. Zhong-Yu Zhou,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
    2. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650 (China)
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    • These authors contributed equally to this work.

  • Dr. Guo-Qing Shi,

    1. Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
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    • These authors contributed equally to this work.

  • Dr. Robert Fontaine,

    1. Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
    2. United States Centers for Disease Control and Prevention, Atlanta, GA 30333 (USA)
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  • Kun Wei,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Tao Feng,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Fang Wang,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Gang-Qiang Wang,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Yan Qu,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Zheng-Hui Li,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Ze-Jun Dong,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Hua-Jie Zhu,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Zhu-Liang Yang,

    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • Prof. Guang Zeng,

    Corresponding author
    1. Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
    • Chinese Center for Disease Control and Prevention, Beijing 100050 (China)
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  • Prof. Dr. Ji-Kai Liu

    Corresponding author
    1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
    • State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 (China)
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  • This project was supported by the National Basic Research Program of China (973 Program, 2009CB522300), the National Natural Sciences Foundation of China (30830113, U1132607), and Scientific Research Special Funds from the Ministry of Health (200802002). We thank Dr. R. Stone for reading our manuscript and for helpful suggestions.

Abstract

original image

Life saver: Two unusual and toxic amino acids, 2R-amino-4S-hydroxy-5-hexynoic acid (red, see scheme) and 2R-amino-5-hexynoic acid (blue) have been isolated from the fruiting bodies of the mushroom Trogia venenata. Toxicology studies suggest that these compounds may be the cause of Sudden Unexplained Death (SUD) in Yunnan Province, China.

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