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Keywords:

  • C[BOND]H activation;
  • copper;
  • fluorine;
  • homogeneous catalysis;
  • iridium
Thumbnail image of graphical abstract

The old one two: A sequential iridium-catalyzed borylation and copper-catalyzed trifluoromethylation of arenes is described (see scheme; Pin=pinacol). The reaction is conducted under mild reaction conditions and tolerates a variety of functional groups. The advantages of this tandem procedure are demonstrated by the late-stage trifluoromethylation of a number of biologically active molecules.