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Keywords:

  • boronic acids;
  • cross-coupling;
  • fluorine;
  • homogeneous catalysis;
  • trifluoroethylation
Thumbnail image of graphical abstract

Trifluoroethylation: Aryl boronic acids can be catalytically trifluoroethylated with the readily available reagent CF3CH2I (see scheme, dba=dibenzylideneacetone). The reaction tolerates a variety of functional groups and can be extended to the trifluoroethylation of aryl or alkenyl boronic esters. The method is also suitable for the late-stage installation of the CF3CH2 group into target molecules.