Support of our work by the National Natural Science Foundation of China (20825209, 20832008) and the Chinese Academy of Sciences is gratefully acknowledged.
Palladium-Catalyzed 2,2,2-Trifluoroethylation of Organoboronic Acids and Esters†
Article first published online: 13 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 1033–1036, January 23, 2012
How to Cite
Zhao, Y. and Hu, J. (2012), Palladium-Catalyzed 2,2,2-Trifluoroethylation of Organoboronic Acids and Esters. Angew. Chem. Int. Ed., 51: 1033–1036. doi: 10.1002/anie.201106742
- Issue published online: 17 JAN 2012
- Article first published online: 13 DEC 2011
- Manuscript Received: 22 SEP 2011
- National Natural Science Foundation of China. Grant Numbers: 20825209, 20832008
- Chinese Academy of Sciences
- boronic acids;
- homogeneous catalysis;
Trifluoroethylation: Aryl boronic acids can be catalytically trifluoroethylated with the readily available reagent CF3CH2I (see scheme, dba=dibenzylideneacetone). The reaction tolerates a variety of functional groups and can be extended to the trifluoroethylation of aryl or alkenyl boronic esters. The method is also suitable for the late-stage installation of the CF3CH2 group into target molecules.