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Anchored Proteinase-Targetable Optomagnetic Nanoprobes for Molecular Imaging of Invasive Cancer Cells

Authors

  • Joseph Park,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
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    • These authors contributed equally to this work.

  • Prof. Jaemoon Yang,

    1. Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
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    • These authors contributed equally to this work.

  • Eun-Kyung Lim,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
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  • Eunjung Kim,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
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  • Jihye Choi,

    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
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  • Joo Kyung Ryu,

    1. Department of Oral pathology, Oral Cancer Research Institute, Yonsei University, Seoul 120-752 (Republic of Korea)
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  • Nam Hee Kim,

    1. Department of Oral pathology, Oral Cancer Research Institute, Yonsei University, Seoul 120-752 (Republic of Korea)
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  • Prof. Jin-Suck Suh,

    1. Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
    3. Severance Biomedical Science Institute (SBSI), Seoul 120-749 (Republic of Korea)
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  • Prof. Jong In Yook,

    1. Department of Oral pathology, Oral Cancer Research Institute, Yonsei University, Seoul 120-752 (Republic of Korea)
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  • Prof. Yong-Min Huh,

    Corresponding author
    1. Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
    3. Severance Biomedical Science Institute (SBSI), Seoul 120-749 (Republic of Korea)
    • Department of Radiology, Yonsei University, Seoul 120-752 (Republic of Korea)
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  • Prof. Seungjoo Haam

    Corresponding author
    1. Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
    2. YUHS-KRIBB Medical Convergence Research Institute, Seoul 120-752 (Republic of Korea)
    • Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749 (Republic of Korea)
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  • This work was supported by the Korea Science and Engineering Foundation grant funded by the Korean government (M10755020001-07N5502-00110), the KRIBB Research Initiative Program (7-2009-0326), National Research Foundation of Korea Grant funded by the Korean Government (MEST) (2010-0019923) and a grant of the Korea Healthcare technology R&D Project, Ministry for Health & Welfare Affairs, Republic of Korea (A085136)

Abstract

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Activatable nanoprobe: A dual-function nanoprobe has been developed that detects membrane type 1-matrix metalloproteinase (MT1-MMP) activity by a dual-signal increase in complementary fluorescence imaging (FI) and magnetic resonance imaging (MRI). MNCs=magnetic nanocrystals, Q=quencher, F=fluorescence dye.

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