SEARCH

SEARCH BY CITATION

Keywords:

  • biofilms;
  • carolacton;
  • Duthaler–Hafner aldol reaction;
  • Marshall reaction;
  • Negishi–Fu reaction;
  • total synthesis
Thumbnail image of graphical abstract

Metals are the key players in the synthesis of caralacton, a strong inhibitor of bacterial biofilms. The total synthesis is based on several metal-mediated key transformations such as the Ley and the Duthaler–Hafner aldol reactions, the Marshall reaction and Breit's substitution, as well as the Nozaki–Hiyama–Kishi and Negishi–Fu C[BOND]C coupling reactions.