Selective Artificial Transmembrane Channels for Protons by Formation of Water Wires


  • J.-L. Hou thanks the NSFC (grant numbers 20902012 and 91027008), the STCSM (grant number 10J1401200), the Innovation Program of SHMEC (grant number 10ZZ01), and the Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials for financial support. We thank Prof. Jiang Si for beneficial discussions.


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Lined up water molecules: Artificial transmembrane channels from pillar[5]arene monomeric and dimeric derivatives have been prepared. Single-channel conductance measurements and isotopeeffect experiments under acidic conditions showed selective proton transport through the channels, which were mediated by water wires formed in the pillar[5]arene backbones (see picture).