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Keywords:

  • fluorescent probes;
  • natural products;
  • phosphopeptides;
  • protein labeling;
  • protein–protein interactions
Thumbnail image of graphical abstract

Fluorescent combination: Cell-penetrating probes derived from the diterpene fusicoccin can form ternary complexes with 14–3–3 proteins and phosphopeptide ligands, whereupon the probes site-specifically attach a fluorescent tag onto the surface of the 14–3–3 proteins.