Fluorescent Probes for the Detection of Hydrogen Sulfide in Biological Systems

Authors

  • Weimin Xuan,

    1. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
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  • Prof. Dr. Chunquan Sheng,

    Corresponding author
    1. Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
    • Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433 (China)
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  • Yanting Cao,

    1. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
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  • Wenhan He,

    1. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
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  • Prof. Dr. Wei Wang

    Corresponding author
    1. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
    2. School of Pharmacy, East China University of Science & Technology, 130 Mei-Long Road, Shanghai 200237 (China)
    • Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001 (USA)
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  • Financial support of the authors′ research is provided by the National Science Foundation (CHE-1057569), the China 111 Project (Grant B07023), and the East China University of Science & Technology, and is gratefully acknowledged.

Abstract

original image

Detective work: Three highly sensitive and selective fluorescent probes for the detection of H2S have been developed. Two of the probes detect H2S by the reduction of an azide moiety to an amine group, which changes the probes into their fluorescent forms and generates a fluorescent signal. In the third method, the fluorescent signal is created by using H2S as a nucleophile in a reaction that unmasks fluorescein.

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