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Keywords:

  • alkaloids;
  • asymmetric catalysis;
  • Brønsted acids;
  • organocatalysis;
  • total synthesis
Thumbnail image of graphical abstract

Something constructive: The title reaction involving 3-hydroxyoxindoles gives 3,3′-disubstituted oxindoles with concomitant generation of an all-carbon quaternary stereogenic center in high yield and excellent enantioselectivity. This reaction enabled the enantioselective construction of hexahydropyrroloindole skeletons and the first catalytic enantioselective total synthesis of (+)-folicanthine.