We thank L. Bayer, S. Granata, A. Sihorsch, and S. Herok-Schöpper for synthetic assistance, V. Brachvogel, A. Liesum, and P. Lönze for support with X-ray structure determination, and Dr. M. Lorenz for discussions.
Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein–Ligand Complexes†
Article first published online: 21 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 905–911, January 23, 2012
How to Cite
Nazaré, M., Matter, H., Will, D. W., Wagner, M., Urmann, M., Czech, J., Schreuder, H., Bauer, A., Ritter, K. and Wehner, V. (2012), Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein–Ligand Complexes. Angew. Chem. Int. Ed., 51: 905–911. doi: 10.1002/anie.201107091
- Issue published online: 17 JAN 2012
- Article first published online: 21 DEC 2011
- Manuscript Revised: 22 NOV 2011
- Manuscript Received: 6 OCT 2011
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