This work is supported by the Swiss National Research Foundation (grant No. 200020-126663) and COST action D40 (SER contract No. C07.0097). The authors warmly thank Dr. Jean-Baptiste Langlois for his valuable advice. We also thank BASF for the generous gift of chiral amines.
Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation†
Article first published online: 8 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 1055–1058, January 23, 2012
How to Cite
Li, H. and Alexakis, A. (2012), Enyne Chlorides: Substrates for Copper-Catalyzed Asymmetric Allylic Alkylation. Angew. Chem. Int. Ed., 51: 1055–1058. doi: 10.1002/anie.201107129
- Issue published online: 17 JAN 2012
- Article first published online: 8 DEC 2011
- Manuscript Received: 8 OCT 2011
- Swiss National Research Foundation. Grant Number: 200020-126663
- COST. Grant Number: C07.0097
- asymmetric catalysis;
- Grignard reagents
A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.