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Keywords:

  • alkylation;
  • asymmetric catalysis;
  • copper;
  • enynes;
  • Grignard reagents
Thumbnail image of graphical abstract

A select few: Several prochiral enyne chlorides were employed as substrates in the title reaction using Grignard reagents as the alkylation reagents (see scheme; CuTC=copper(I) thiophenecarboxylate). Excellent 1,3 substitution regioselectivities and good to excellent enantioselectivities were obtained. The substrate scope is additionally extended to diene chlorides.