Communication

Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells†

  1. Leonid Vigderman,
  2. Dr. Pramit Manna,
  3. Prof. Eugene R. Zubarev*

Article first published online: 15 NOV 2011

DOI: 10.1002/anie.201107304

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 3, pages 636–641, January 16, 2012

Additional Information

How to Cite

Vigderman, L., Manna, P. and Zubarev, E. R. (2012), Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells. Angew. Chem. Int. Ed., 51: 636–641. doi: 10.1002/anie.201107304

Author Information

  1. Department of Chemistry, Rice University, Houston, TX 77005 (USA) http://www.owlnet.rice.edu/∼zubarev/

*Department of Chemistry, Rice University, Houston, TX 77005 (USA) http://www.owlnet.rice.edu/∼zubarev/

  1. †

    This work was supported by the NSF (grant numbers DMR-0547399 and DMR-1105878).

Publication History

  1. Issue published online: 12 JAN 2012
  2. Article first published online: 15 NOV 2011
  3. Manuscript Received: 17 OCT 2011

Funded by

  • NSF. Grant Numbers: DMR-0547399, DMR-1105878

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Keywords:

  • cancer cells;
  • cellular uptake;
  • gold;
  • nanorods;
  • surface chemistry
Thumbnail image of graphical abstract

Stable and biocompatible: The chemical composition of synthesized cationic thiolate-monolayer-protected gold nanorods was precisely determined. In vitro cell culture experiments showed no cytotoxicity of these nanorods, and the number of nanorods that were taken up by each cancer cell exceeded two million particles (see picture).

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