This work was supported by the NSF (grant numbers DMR-0547399 and DMR-1105878).
Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells†
Article first published online: 15 NOV 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 3, pages 636–641, January 16, 2012
How to Cite
Vigderman, L., Manna, P. and Zubarev, E. R. (2012), Quantitative Replacement of Cetyl Trimethylammonium Bromide by Cationic Thiol Ligands on the Surface of Gold Nanorods and Their Extremely Large Uptake by Cancer Cells. Angew. Chem. Int. Ed., 51: 636–641. doi: 10.1002/anie.201107304
- Issue published online: 12 JAN 2012
- Article first published online: 15 NOV 2011
- Manuscript Received: 17 OCT 2011
- NSF. Grant Numbers: DMR-0547399, DMR-1105878
- cancer cells;
- cellular uptake;
- surface chemistry
Stable and biocompatible: The chemical composition of synthesized cationic thiolate-monolayer-protected gold nanorods was precisely determined. In vitro cell culture experiments showed no cytotoxicity of these nanorods, and the number of nanorods that were taken up by each cancer cell exceeded two million particles (see picture).