We are grateful for financial support from the NSFC (20902074) and the Fundamental Research Funds for the Central Universities (XDJK2011C054).
Multistep One-Pot Synthesis of Enantioenriched Polysubstituted Cyclopenta[b]indoles†
Article first published online: 13 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 1059–1062, January 23, 2012
How to Cite
Xu, B., Guo, Z.-L., Jin, W.-Y., Wang, Z.-P., Peng, Y.-G. and Guo, Q.-X. (2012), Multistep One-Pot Synthesis of Enantioenriched Polysubstituted Cyclopenta[b]indoles. Angew. Chem. Int. Ed., 51: 1059–1062. doi: 10.1002/anie.201107308
- Issue published online: 17 JAN 2012
- Article first published online: 13 DEC 2011
- Manuscript Received: 17 OCT 2011
- NSFC. Grant Number: 20902074
- Fundamental Research Funds for the Central Universities. Grant Number: XDJK2011C054
- multistep reactions;
- one-pot syntheses;
Simple steps, complex result: Consecutive organo-catalyzed reactions of 3-indolylmethanol compounds with aldehydes and N-protected indoles lead to the formation of structurally complex cyclopenta[b]indoles (see scheme, Bn=benzyl). These one-pot multistep reactions have a broad substrate scope and give the products in high yields, and with excellent diastereoselectivities and enantioselectivities.