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Keywords:

  • alkylations;
  • indoles;
  • multistep reactions;
  • one-pot syntheses;
  • organocatalysis
Thumbnail image of graphical abstract

Simple steps, complex result: Consecutive organo-catalyzed reactions of 3-indolylmethanol compounds with aldehydes and N-protected indoles lead to the formation of structurally complex cyclopenta[b]indoles (see scheme, Bn=benzyl). These one-pot multistep reactions have a broad substrate scope and give the products in high yields, and with excellent diastereoselectivities and enantioselectivities.