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Keywords:

  • C[BOND]H functionalization;
  • energy diagrams;
  • isotope effects;
  • kinetics;
  • rate-determining step
Thumbnail image of graphical abstract

Rate versus selectivity determining: The measurement of a kinetic isotope effect (KIE) can provide valuable information about the mechanism of a reaction, but care must be taken in the design and interpretation of KIE experiments. Depending on the experiment that is conducted, the observation of a primary KIE resulting from H/D substitution does not necessarily imply that C[BOND]H bond cleavage occurs during the rate-determining step of a reaction. FG=functional group.