We thank the National Science Foundation (ECCS-1045621 and CBET-1037097) for financial support.
Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers†
Article first published online: 23 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 5, pages 1236–1239, January 27, 2012
How to Cite
Sun, Y. and Fan, X. (2012), Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers. Angew. Chem. Int. Ed., 51: 1236–1239. doi: 10.1002/anie.201107381
- Issue published online: 24 JAN 2012
- Article first published online: 23 DEC 2011
- Manuscript Revised: 29 NOV 2011
- Manuscript Received: 19 OCT 2011
- National Science Foundation. Grant Numbers: ECCS-1045621, CBET-1037097
- molecular beacons;
Laser precision: A highly sensitive technique based on laser emission for differentiating a target DNA strand from strands that contain single base mismatches has been developed. Laser emission is used to amplify the small difference in signals that are generated by the different strands after hybridization with a molecular beacon (MB, see picture) in a conversion that is similar to analog-to-digital.