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Distinguishing DNA by Analog-to-Digital-like Conversion by Using Optofluidic Lasers

Authors

  • Dr. Yuze Sun,

    1. Biomedical Engineering Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI 48109 (USA)
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  • Prof. Dr. Xudong Fan

    Corresponding author
    1. Biomedical Engineering Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI 48109 (USA)
    • Biomedical Engineering Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI 48109 (USA)
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  • We thank the National Science Foundation (ECCS-1045621 and CBET-1037097) for financial support.

Abstract

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Laser precision: A highly sensitive technique based on laser emission for differentiating a target DNA strand from strands that contain single base mismatches has been developed. Laser emission is used to amplify the small difference in signals that are generated by the different strands after hybridization with a molecular beacon (MB, see picture) in a conversion that is similar to analog-to-digital.

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