Ortho-Trifluoromethylation of Functionalized Aromatic Triazenes

Authors

  • Dipl.-Chem. Andreas Hafner,

    1. Institute of Organic Chemistry, KIT-Campus South, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)
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  • Prof. Dr. Stefan Bräse

    Corresponding author
    1. Institute of Organic Chemistry, KIT-Campus South, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)
    • Institute of Organic Chemistry, KIT-Campus South, Fritz-Haber-Weg 6, 76131 Karlsruhe (Germany)
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  • We thank the Landesgraduiertenförderung Baden-Württemberg for financial support.

Abstract

original image

A silver key to add CF3: In presence of in situ generated AgCF3, it is possible to trifluoromethylate aromatic triazenes in high ortho selectivity and good yields by means of a C[BOND]H substitution (see scheme). Owing to the further transformation possibilities offered by triazenes, a variety of CF3-substituted building blocks are then accessible.

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