We thank the Max-Planck Society for generous financial support. F.L. is the recipient of a postdoctoral fellowship from Fonds québécois de la recherche sur la nature et les technologies (FQRNT). Vapourtec is gratefully acknowledged for providing R2C+ and R4 flow-chemistry systems. We thank Dr. V. Mountain for critically editing this manuscript and Ms. C. Steininger for drawing Figure 1.
Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin†
Article first published online: 16 JAN 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 7, pages 1706–1709, February 13, 2012
How to Cite
Lévesque, F. and Seeberger, P. H. (2012), Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin. Angew. Chem. Int. Ed., 51: 1706–1709. doi: 10.1002/anie.201107446
- Issue published online: 7 FEB 2012
- Article first published online: 16 JAN 2012
- Manuscript Received: 21 OCT 2011
- Max-Planck Society
- Fonds québécois de la recherche sur la nature et les technologies (FQRNT)
- drug research;
- flow chemistry;
Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.