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Communication

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin†

  1. Dr. François Lévesque1,
  2. Prof. Dr. Peter H. Seeberger1,2,*

Article first published online: 16 JAN 2012

DOI: 10.1002/anie.201107446

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 7, pages 1706–1709, February 13, 2012

Additional Information

How to Cite

Lévesque, F. and Seeberger, P. H. (2012), Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin. Angew. Chem. Int. Ed., 51: 1706–1709. doi: 10.1002/anie.201107446

Author Information

  1. 1

    Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

  2. 2

    Institute for Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany) http://www.mpikg.mpg.de

*Department for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam (Germany)

  1. †

    We thank the Max-Planck Society for generous financial support. F.L. is the recipient of a postdoctoral fellowship from Fonds québécois de la recherche sur la nature et les technologies (FQRNT). Vapourtec is gratefully acknowledged for providing R2C+ and R4 flow-chemistry systems. We thank Dr. V. Mountain for critically editing this manuscript and Ms. C. Steininger for drawing Figure 1.

Publication History

  1. Issue published online: 7 FEB 2012
  2. Article first published online: 16 JAN 2012
  3. Manuscript Received: 21 OCT 2011

Funded by

  • Max-Planck Society
  • Fonds québécois de la recherche sur la nature et les technologies (FQRNT)

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Keywords:

  • artemisinin;
  • drug research;
  • flow chemistry;
  • malaria;
  • photochemistry
Thumbnail image of graphical abstract

Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.

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