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Keywords:

  • follicle-stimulating hormone;
  • glycoproteins;
  • native chemical ligation;
  • solid-phase peptide synthesis
Thumbnail image of graphical abstract

Ambitious undertaking: The β-subunit of the human follicle-stimulating hormone (hFSH) displaying a N-linked consensus sequence oligosaccharide at each of the two wild-type sites was synthesized. The glycoprotein has been designed with acetamidomethyl protected cysteine residues, anticipating folding and association with the α-subunit. This represents the largest realistically glycosylated homogeneous glycoprotein obtained by using strictly chemical methods.