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Programmed Dynamic Topologies in DNA Catenanes

Authors

  • Johann Elbaz,

    1. Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
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    • These authors contributed equally to this work.

  • Dr. Zhen-Gang Wang,

    1. Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
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    • These authors contributed equally to this work.

  • Dr. Fuan Wang,

    1. Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
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  • Prof. Itamar Willner

    Corresponding author
    1. Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
    • Institute of Chemistry, Center of Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel)
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  • This study was supported by the Volkswagen Foundation (Germany). J.E. acknowledges a Converging Technologies Fellowship (Israel Science Foundation).

Abstract

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Linking in: Two-ring and three-ring catenane nanostructures that are made from sequences of DNA have been shown to undergo programmed and reversible reconfiguration across defined topologies by using strand displacement. The switchable nature of the configurations may enable a more flexible approach to the transport and delivery of molecular cargoes, or for the use of such structures as labels in an intracellular environment.

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