Is Enantiomer Assignment Possible by NMR Spectroscopy Using Residual Dipolar Couplings from Chiral Nonracemic Alignment Media?—A Critical Assessment


  • Authors listed in alphabetical order. R.B., C.G., M.K., B.L., M.R., U.M.R., C.M.T., and M.Z. thank the DFG for FOR 934. J.C., P.L., and D.M. thank the CNRS for recurrent funding. R.R.G. thanks the NSF (grant number CHE-1111684). A.N.V. thanks for funding from Xunta de Galicia/FEDER (grant number CE2009/071) and the Spanish government for “Ramón y Cajal” contract.


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Insensitive towards inversion: Can residual dipolar couplings (RDCs) and other anisotropic NMR observables be used to determine absolute configuration? A critical assessment of recent approaches is provided to determine the absolute configuration from RDCs.