First Solution Structures of Seven-Transmembrane Helical Proteins


  • Dr. Reto Walser is acknowledged for valuable comments on this manuscript.


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A mastered challenge: The recent solution structures of seven-transmembrane proteins, in particular of proteorhodopsin, have been reported. The structures are a major advance in structural biology and were determined based on experimental restrains derived from nuclear Overhauser effects (NOEs), paramagnetic relaxation enhancements (PREs), and residual dipolar couplings (RDCs, see picture).