Dr. Reto Walser is acknowledged for valuable comments on this manuscript.
First Solution Structures of Seven-Transmembrane Helical Proteins†
Article first published online: 16 DEC 2011
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 4, pages 860–861, January 23, 2012
How to Cite
Zerbe, O. (2012), First Solution Structures of Seven-Transmembrane Helical Proteins. Angew. Chem. Int. Ed., 51: 860–861. doi: 10.1002/anie.201107639
- Issue published online: 17 JAN 2012
- Article first published online: 16 DEC 2011
- Manuscript Received: 30 OCT 2011
- cell-free expression;
- membrane proteins;
- NMR spectroscopy;
- structural biology
A mastered challenge: The recent solution structures of seven-transmembrane proteins, in particular of proteorhodopsin, have been reported. The structures are a major advance in structural biology and were determined based on experimental restrains derived from nuclear Overhauser effects (NOEs), paramagnetic relaxation enhancements (PREs), and residual dipolar couplings (RDCs, see picture).