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Keywords:

  • amino alcohols;
  • aminohydroxylation;
  • cyclization;
  • hypervalent iodine;
  • stereoselective synthesis
Thumbnail image of graphical abstract

The ring and I: Hypervalent iodine compounds avoid the issues of toxicity or complicated ligands of many transition-metal-based systems. A highly enantioselective oxyamination of alkenes with N-sulfonyl ureas employing chiral, lactic acid-based hypervalent iodine reagents gives a facile synthesis of enantiomerically pure 2-arylproline derivatives (see scheme) for the first time.