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An Autonomous and Controllable Light-Driven DNA Walking Device

Authors

  • Mingxu You,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Dr. Yan Chen,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Prof. Dr. Xiaobing Zhang,

    Corresponding author
    1. State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
    • State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
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  • Dr. Haipeng Liu,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Dr. Ruowen Wang,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Dr. Kelong Wang,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Dr. Kathryn R. Williams,

    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • Prof. Dr. Weihong Tan

    Corresponding author
    1. Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
    2. State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)
    • Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200 (USA)
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  • The authors would like to thank the Interdisciplinary Center for Biotechnology Research (ICBR) at the University of Florida for technical support. This work is supported by grants awarded by the National Institutes of Health (grant numbers GM066137, GM079359, and CA133086) and by the NSF. This work was also supported by the National Key Scientific Program of China (2011CB911001, 2011CB911003).

Abstract

original image

Regulatable nanorobots: A DNA-based walking device was designed that is capable of autonomous locomotion, with light control of initiation, termination, and velocity (see picture). This device is reminiscent of cellular protein motors in nature, especially those of green plants.

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