A Chiral Bis(betaine) Catalyst for the Mannich Reaction of Azlactones and Aliphatic Imines


  • We are grateful for financial support from the Chinese Academy of Sciences, MOST (973 project 2010CB833300), the Ministry of Education, and BASF (GLZ).


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By design: New chiral bis(betaine)s, for example 1, containing two catalytically active centers have been designed. They have proven to be promising organocatalysts for the direct Mannich-type reaction of azlactones with a broad spectrum of aliphatic imines, thus affording α-tetrasubstituted α,β-diamino acid surrogates with excellent enantioselectivities.