Temperature-Responsive “Catch and Release” of Proteins by using Multifunctional Polymer-Based Nanoparticles


  • Financial support from the National Institutes of Health (GM 080506) is gratefully acknowledged. B.K.L. was a recipient of Allergan Undergraduate Research Fellowship.


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Catch me if you can: Multifunctional, polymer-based nanoparticles that are capable of temperature-responsive “catch-and-release” of a target protein have been synthesized. The process is reversible and does not denature the proteins. An optimized combination of functional monomers imparts binding selectivity toward a target protein over other proteins.