Communication

Bio-Inspired Design and Potential Biomedical Applications of a Novel Class of High-Affinity Peptides†

  1. Sunghyun Kim1,
  2. Daejin Kim1,
  3. Hyun Ho Jung1,
  4. In-Hyun Lee1,
  5. Prof. Jae IL Kim1,
  6. Prof. Jeong-Yong Suh2,
  7. Prof. Sangyong Jon1,*

Article first published online: 24 JAN 2012

DOI: 10.1002/anie.201107894

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 51, Issue 8, pages 1890–1894, February 20, 2012

Additional Information

How to Cite

Kim, S., Kim, D., Jung, H. H., Lee, I.-H., Kim, J. I., Suh, J.-Y. and Jon, S. (2012), Bio-Inspired Design and Potential Biomedical Applications of a Novel Class of High-Affinity Peptides. Angew. Chem. Int. Ed., 51: 1890–1894. doi: 10.1002/anie.201107894

Author Information

  1. 1

    School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju 500-712 (South Korea)

  2. 2

    Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak-ro, Seoul 151-921 (South Korea)

*School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Gwangju 500-712 (South Korea)

  1. †

    This work was supported by a grant from the National Research Foundation of Korea (NRF), MEST (grant number: 20110000143) and by a grant from Cell Dynamics Research Center, KOSEF (grant number: 20110001163).

Publication History

  1. Issue published online: 14 FEB 2012
  2. Article first published online: 24 JAN 2012
  3. Manuscript Revised: 12 DEC 2011
  4. Manuscript Received: 9 NOV 2011

Funded by

  • National Research Foundation of Korea (NRF)
  • MEST. Grant Number: 20110000143
  • KOSEF. Grant Number: 20110001163

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Keywords:

  • aptides;
  • imaging agents;
  • peptides;
  • peptide design;
  • phage display
Thumbnail image of graphical abstract

Two arms to hold: Inspired by the structure of basic leucine-zipper proteins, high-affinity peptides, named aptides, were designed that contain a stabilizing scaffold (tryptophan zipper) and two target-binding regions (orange and blue in picture). A fluorescently labeled aptide that binds to a tumor-specific protein was used for fluorescence imaging in vivo.

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