Effects of the Stationary Phase and the Solvent on the Stereodynamics of biphep Ligands Quantified by Dynamic Three-Column HPLC


  • Generous financial support from the European Research Council (ERC) (Starting Grant No. 258740, AMPCAT, to O.T.) is gratefully acknowledged. We thank Dr. John M. Brown, Oxford University, for the substituted biphep ligands and for helpful discussions.


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Dynamics and kinetics in a single stroke: The stereodynamics of the tropos-chiral diphosphine biphep and its 3,3′-dialkoxy analogues were investigated by enantioselective dynamic HPLC (DHPLC) and a novel three-column approach, in with the dynamics and kinetics of the interconversion were examined in a single experimental setup (see scheme).